ER and PR signaling nodes during mammary gland development
نویسندگان
چکیده
منابع مشابه
PPAR signaling exacerbates mammary gland tumor development
Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor (PPAR ) can be prompted to undergo growth arrest and differentiation when treated with synthetic PPAR ligands. To evaluate the therapeutic potential of increased PPAR signaling in vivo, we generated transgenic mice that express a constitutively active form of PPAR in mammary gland. These mice are indist...
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متن کاملTitle: Progesterone Receptor Isoforms A and B: Temporal and Spatial Differences in Expression During Murine Mammary Gland Development Running Title: PR isoform expression in mammary gland
Grant and fellowship support: This publication was made possible by the Breast Cancer and the Environment Research Centers grant number U01 ES/CA 012800 from the National Institute of Environment Health Science (NIEHS), and the National Cancer Institute (NCI), NIH, DHHS to S.Z. H. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of th...
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To identify functions of the IKKalpha subunit of IkappaB kinase that require catalytic activity, we generated an Ikkalpha(AA) knockin allele containing alanines instead of serines in the activation loop. Ikkalpha(AA/AA) mice are healthy and fertile, but females display a severe lactation defect due to impaired proliferation of mammary epithelial cells. IKKalpha activity is required for NF-kappa...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2012
ISSN: 1465-542X
DOI: 10.1186/bcr3166